Research & Commentary Results

This week, US President Donald Trump makes his inaugural visit to the Middle East since the start of his second term, traveling to Saudi Arabia, Qatar, and the United Arab Emirates on May 13-16. Amid the heightened focus on US policy toward the Middle East, MEI’s experts take stock of Trump’s trip to the Gulf, how his administration has shaped its approach to the wider region in its first several months, and how regional actors are responding to the policies coming out of Washington.

President Donald J. Trump’s trip to the Middle East on May 13-16 comes on the heels of more than three months of whirlwind activity in US foreign policy where the region has been a higher priority than it was in the early months of the previous US administration. The US president has gained attention by proposing some provocative ideas and his team has made some signs of progress in talks with Iran, but thus far the second Trump administration has produced very few tangible advances for stability, prosperity, and progress in the Middle East. The following report assesses the US government’s actions on Middle East policy over the past three months, from late January to late April 2025.

As Saudi Arabia accelerates its transformation into a global technology powerhouse, the United States has a pivotal opportunity to redefine its partnership with the kingdom. Moving beyond the traditional oil-for-security framework, a new partnership centered on artificial intelligence and digital infrastructure can anchor US-Saudi relations in the 21st century.​

President Donald Trump reached the 100-day mark in his second term this week seeing a sharp drop in his domestic political standing. This comes less than two weeks before Trump embarks on a key Middle East trip to the Gulf. The administration may be looking to the presidential visit as a chance to achieve some progress, but the region remains fraught with uncertainty and US policy in the Middle East rarely provides domestic political dividends.

Iran appears to be reorienting its approach to diplomatic engagement with its neighbors and the West by prioritizing the economic benefits of cooperation. A possible withdrawal of support for the Houthis is the latest significant potential outcome of Iran’s shifting stance. The following are five factors to watch for as a Tehran under duress reformulates its policies.

Following seven years of diplomatic deadlock, Washington and Tehran have resumed nuclear negotiations — and for the first time in years, there are signs of real momentum.

Alex Vatanka, MEI Senior Fellow and author of The Battle of the Ayatollahs in Iran, joins hosts Alistair Taylor and Matthew Czekaj to analyze the current round of talks, the technical issues under discussion, and the political stakes on both sides. He explores Iran’s economic and domestic pressures, US red lines, and the role of key players like Israel, China, and Oman in shaping the negotiations.

The spotlight on US policy in the Middle East remains focused on talks with Iran, with a third round set for Oman this coming weekend after discussions in Rome on April 19 offered some signs of progress. But a growing humanitarian crisis in the Gaza Strip and the stalled efforts to safely return hostages held by Hamas remain the biggest challenges that President Donald Trump’s administration has yet to address successfully.

President Donald Trump wants a deal with Iran. Russia has offered to mediate. But an agreement negotiated by Moscow would turn the Middle East upside down as well as negate years of Western efforts to impede and deter further aggression by the Kremlin.

On April 12, the United States and Iran wrapped up their first round of renewed diplomatic talks in Muscat, with round two set for April 19, in Rome. In the interim, Iranian Foreign Minister Abbas Araghchi is in Moscow to coordinate with the Russians. But the real breakthrough will not come from nuclear talks alone — it will require confronting the region’s most explosive fault line: the Iranian-Israeli standoff. Russia claims it can help.

It is no surprise that both Iran and the United States have approached their first diplomatic engagement in four years with wariness. There are plenty of reasons to be skeptical about the probability of the negotiations culminating in a deal. But it would be a mistake to assume that the conditions in 2025 are the same as existed in 2015. Time is not on the Iranians’ side now and changes afoot in the Middle East and the broader global community give Iran an incentive to move toward an agreement, assuming that Washington is sincere and realistic in its negotiations with Tehran.

This article is published as part of the Perry World House workshop “U.S.-Iran Relations Under Trump 2.0: Lessons Learned and Likely Scenarios.”

The biggest development this past week in the Middle East policy of Trump’s second administration was the initiation of talks between the United States and Iran. This small sign of hope for diplomatic progress comes at a time when the administration continues to implement an assertive and unpredictable economic unilateralism that has roiled global markets and reduced trust and confidence between the United States and most close international partners. Brian Katulis unpacks three things to watch closely as Trump’s Iran policy evolves and his broader national security approach unfolds.

Sheikh Tahnoon bin Zayed, the United Arab Emirates’ national security adviser and a central figure in its tech and security landscape, visited Washington for high-level engagement with President Donald Trump’s team late last month, signaling a transformative shift in UAE-US relations.

The MENA Energy Recap is a quarterly review of key energy developments that took place in the Middle East and North Africa region from January to March 2025 and what they signal for the months ahead. The Recap views these developments through the lenses of policy and strategy, energy security, and markets.

US President Donald Trump surprised Israeli Prime Minister Benjamin Netanyahu by publicly announcing “direct” talks between the United States and Iran set to take place later this week. The American president also unleashed global economic uncertainty by announcing simultaneous, unexpectedly high tariffs on dozens of countries around the world — including a 17% duty on Israel — and kicking off an escalating global trade war.