During two days of meetings in May 2022, members of the Middle East Dialogue, convened by MEI, met in Istanbul, Turkey to discuss pressing issues relating to: i) the effects of the war in Ukraine on the MENA region; ii) current and future projections regarding Gulf relations with Iran, amid the stalemate over a revival of the 2015 JCPOA; iii) the future pathways and security framework for the MENA region; and iv) the Baghdad Declaration of Good Neighborhood Principles for the Middle East. This meeting brought together policymakers, academics, and experts from across the MENA region. This report provides an analytical understanding of the issues discussed and recommendations shared during the meeting.