Research & Commentary Results

The evolving confrontation with Israel and the United States places the Islamic Republic of Iran at a critical inflection point. Tehran faces choices that range from limited negotiation and strategic restraint to escalation and eventual collapse. The following analysis explores the key scenarios that could unfold in the coming days, weeks, and years.

Senior Fellow Alex Vatanka joins hosts Alistair Taylor and Matthew Czekaj to examine the dramatic escalation between Israel and Iran following Israel’s targeted strikes on Iranian nuclear sites, infrastructure, and senior IRGC officials. Vatanka discusses how the Iranian regime is responding, the risk of wider regional conflict, and whether the current campaign could mark the beginning of the end for the Islamic Republic.

The past four days have clarified much about what Israel wants from this conflict, what Iran can and cannot do to fight back, and what decisions confront the American president over the next few days.

The spotlight in America this week is trained on the home front, with growing tensions inside the country over President Donald Trump’s immigration crackdown and a showdown unfolding on the streets of Los Angeles. At times like these, the rest of the world has a way of intruding, sometimes unexpectedly, and Trump 2.0’s foreign policy is still struggling to produce a major positive outcome from its frenetic activity trying to end kinetic wars while prosecuting an unprecedented economic war with much of the rest of the world.

What’s next for Gaza—and for Israel? In this episode of Middle East Focus, hosts Alistair Taylor and Matthew Czekaj sit down with Ghaith al-Omari, senior fellow at the Washington Institute for Near East Policy and former advisor to the Palestinian Authority, to unpack the urgent humanitarian crisis gripping Gaza, the impact of Israeli settlement expansion, and what these developments mean for the future of the region.

What has been unfolding in the Gaza Strip for millions of Palestinians is the direct consequence of the failures of political leaders who are ignoring best practices for the delivery of aid to innocent people caught in the crosshairs of a complicated war. Without a major shift in the current approach, the already dire conditions are only likely to deteriorate further going forward.

The harsh realities of the region’s threats and challenges, like Iran and the Gaza war, stubbornly persist following the pomp and circumstance of Trump’s “spring bling” tour, which featured eye-popping dollar figures and an offer of a luxury jumbo jet from Qatar.

Ambassador Dennis Ross joins host Brian Katulis to break down what President Trump’s recent trip through Saudi Arabia, the UAE, and Qatar revealed about the administration’s approach to foreign policy in the Middle East—and what it means for the future of the region. They discuss the significance and substance behind the announced mega-deals, what’s really going on with Iran and the Houthi ceasefire, and how Trump is handling relations with Israel amid the ongoing war in Gaza.

Two recent developments present the new Syrian government with a critical opportunity to stabilize the country. First, US President Donald Trump announced plans to lift sanctions on Syria. Second, the Kurdistan Workers’ Party declared it would disband and dissolve itself — a move that will help Damascus to finalize a deal with the Syrian Democratic Forces and integrate it into the new Syrian national army. President Trump should build on this momentum and seize the opportunity to address one of the most complex remaining challenges facing Syria: the risk of a military confrontation between Turkey and Israel inside the country.

One of the strategic thrusts of the opening months of Trump’s second terms has been aimed at deepening America’s economic engagement with the leading economies of the Gulf. Thus, the first leg of his trip to the region resulted in a template for deeper US-Saudi ties.

Neoconservatives and MAGA isolationists are locked in a battle for the soul of Republican strategy. Nowhere is the split more glaring than over the Middle East: hawks view it as a proving ground for American power and allegiance to Israel, while isolationists see only endless wars that have bled America dry. Where does Trump fall in this tug-of-war?

President Donald Trump reached the 100-day mark in his second term this week seeing a sharp drop in his domestic political standing. This comes less than two weeks before Trump embarks on a key Middle East trip to the Gulf. The administration may be looking to the presidential visit as a chance to achieve some progress, but the region remains fraught with uncertainty and US policy in the Middle East rarely provides domestic political dividends.

The spotlight on US policy in the Middle East remains focused on talks with Iran, with a third round set for Oman this coming weekend after discussions in Rome on April 19 offered some signs of progress. But a growing humanitarian crisis in the Gaza Strip and the stalled efforts to safely return hostages held by Hamas remain the biggest challenges that President Donald Trump’s administration has yet to address successfully.

On April 12, the United States and Iran wrapped up their first round of renewed diplomatic talks in Muscat, with round two set for April 19, in Rome. In the interim, Iranian Foreign Minister Abbas Araghchi is in Moscow to coordinate with the Russians. But the real breakthrough will not come from nuclear talks alone — it will require confronting the region’s most explosive fault line: the Iranian-Israeli standoff. Russia claims it can help.

It is no surprise that both Iran and the United States have approached their first diplomatic engagement in four years with wariness. There are plenty of reasons to be skeptical about the probability of the negotiations culminating in a deal. But it would be a mistake to assume that the conditions in 2025 are the same as existed in 2015. Time is not on the Iranians’ side now and changes afoot in the Middle East and the broader global community give Iran an incentive to move toward an agreement, assuming that Washington is sincere and realistic in its negotiations with Tehran.