Research & Commentary Results

President Donald Trump wants a deal with Iran. Russia has offered to mediate. But an agreement negotiated by Moscow would turn the Middle East upside down as well as negate years of Western efforts to impede and deter further aggression by the Kremlin.

On April 12, the United States and Iran wrapped up their first round of renewed diplomatic talks in Muscat, with round two set for April 19, in Rome. In the interim, Iranian Foreign Minister Abbas Araghchi is in Moscow to coordinate with the Russians. But the real breakthrough will not come from nuclear talks alone — it will require confronting the region’s most explosive fault line: the Iranian-Israeli standoff. Russia claims it can help.

It is no surprise that both Iran and the United States have approached their first diplomatic engagement in four years with wariness. There are plenty of reasons to be skeptical about the probability of the negotiations culminating in a deal. But it would be a mistake to assume that the conditions in 2025 are the same as existed in 2015. Time is not on the Iranians’ side now and changes afoot in the Middle East and the broader global community give Iran an incentive to move toward an agreement, assuming that Washington is sincere and realistic in its negotiations with Tehran.

As Sudan’s civil war enters its third year, the humanitarian catastrophe continues to spiral, with more than 12.7 million people displaced and little hope of resolution in sight.

Jehanne Henry, MEI Associate Fellow and former Africa Director at Human Rights Watch, joins hosts Alistair Taylor and Matthew Czekaj to assess the latest developments on the ground. She outlines the scale of devastation, the regional spillover effects, and the war economy fueling the fighting.

This article is published as part of the Perry World House workshop “U.S.-Iran Relations Under Trump 2.0: Lessons Learned and Likely Scenarios.”

The biggest development this past week in the Middle East policy of Trump’s second administration was the initiation of talks between the United States and Iran. This small sign of hope for diplomatic progress comes at a time when the administration continues to implement an assertive and unpredictable economic unilateralism that has roiled global markets and reduced trust and confidence between the United States and most close international partners. Brian Katulis unpacks three things to watch closely as Trump’s Iran policy evolves and his broader national security approach unfolds.

Two years on, the war between the Sudanese Armed Forces and the paramilitary Rapid Support Forces has created the world’s largest humanitarian crisis and wrought terrible destruction.

US President Donald Trump surprised Israeli Prime Minister Benjamin Netanyahu by publicly announcing “direct” talks between the United States and Iran set to take place later this week. The American president also unleashed global economic uncertainty by announcing simultaneous, unexpectedly high tariffs on dozens of countries around the world — including a 17% duty on Israel — and kicking off an escalating global trade war.

Almost immediately after the start of the conflict in Gaza, Israeli Prime Minister Benjamin Netanyahu and his governing coalition began a concerted effort to persuade first the European Union and then the United States to pressure Egypt to accept Palestinian refugees. Egypt refused and continues to do so. Capitulating is not in Cairo’s national interest and bullying it will only backfire.

President Donald Trump confirmed this week that he plans to travel to Saudi Arabia and other Middle East countries later this spring. This visit will bring the region into sharper focus at a time when Trump’s priorities have focused closer to home and on his unique brand of economic warfare.

President Donald Trump is focused on realizing two transformative breakthroughs that his predecessors failed to accomplish: an end to the Arab-Israeli conflict, centered on a tripartite US-Saudi-Israeli deal, and an agreement between the US and Iran. Both would be historic achievements. So far, however, progress in each case has proven difficult and plodding.

President Masoud Pezeshkian might be the loneliest man in Iran. Just eight months into his term in office, he is already losing the support of those who once championed him. While the Iranian presidency is a thankless job, Pezeshkian is not helping his own case.

Iran is accumulating enough near-weapons-grade enriched uranium to build a nuclear weapon within weeks or months, not years. President Donald Trump, having withdrawn the United States in 2018 from the nuclear deal that would have postponed that possibility, is now appealing for negotiations with Tehran. But in the Middle East, the nuclear question does not concern only Iran.

President Donald Trump’s administration dialed up its use of military power in the Middle East this past week just as it took more steps to dismantle American institutions central to advancing peace and stability through diplomacy.

After decades of managing tensions through careful balancing, Turkey and Iran now find themselves increasingly at odds following recent shifts in the regional balance of power. With Ankara emboldened and Tehran on its back foot after the fall of the regime of Bashar al-Assad, the struggle for influence between the two neighbors and long-time rivals is escalating in both Syria and Iraq and could spread well beyond their borders.