Research & Commentary Results

Senior Fellow Alex Vatanka joins hosts Alistair Taylor and Matthew Czekaj to examine the dramatic escalation between Israel and Iran following Israel’s targeted strikes on Iranian nuclear sites, infrastructure, and senior IRGC officials. Vatanka discusses how the Iranian regime is responding, the risk of wider regional conflict, and whether the current campaign could mark the beginning of the end for the Islamic Republic.

MEI Senior Fellow Iulia Joja delivers a sharp and timely warning against Russia being offered a direct role in US-Iran negotiations. Far from acting as a neutral broker, Moscow wants to leverage this moment to reshape the balance of power in the Middle East. From meetings in Muscat to tightening alliances with Tehran and Beijing, Joja unpacks how Putin’s diplomacy is less about peace — and more about building up Russian influence against the US. Washington should be paying close attention.

Iran appears to be reorienting its approach to diplomatic engagement with its neighbors and the West by prioritizing the economic benefits of cooperation. A possible withdrawal of support for the Houthis is the latest significant potential outcome of Iran’s shifting stance. The following are five factors to watch for as a Tehran under duress reformulates its policies.

Ukraine faces a pivotal year in its fight against Russian aggression — and for its democratic future. With fears mounting that President Trump could abandon peace talks with Kyiv and Moscow, the risk grows that US disengagement could tip the balance toward Russia and fracture the global democratic order.

Following seven years of diplomatic deadlock, Washington and Tehran have resumed nuclear negotiations — and for the first time in years, there are signs of real momentum.

Alex Vatanka, MEI Senior Fellow and author of The Battle of the Ayatollahs in Iran, joins hosts Alistair Taylor and Matthew Czekaj to analyze the current round of talks, the technical issues under discussion, and the political stakes on both sides. He explores Iran’s economic and domestic pressures, US red lines, and the role of key players like Israel, China, and Oman in shaping the negotiations.

President Donald Trump wants a deal with Iran. Russia has offered to mediate. But an agreement negotiated by Moscow would turn the Middle East upside down as well as negate years of Western efforts to impede and deter further aggression by the Kremlin.

On April 12, the United States and Iran wrapped up their first round of renewed diplomatic talks in Muscat, with round two set for April 19, in Rome. In the interim, Iranian Foreign Minister Abbas Araghchi is in Moscow to coordinate with the Russians. But the real breakthrough will not come from nuclear talks alone — it will require confronting the region’s most explosive fault line: the Iranian-Israeli standoff. Russia claims it can help.

This article is published as part of the Perry World House workshop “U.S.-Iran Relations Under Trump 2.0: Lessons Learned and Likely Scenarios.”

For much of the past two decades, ISIS has enjoyed favorable conditions in Syria, but since the fall of Bashar al-Assad’s regime in December 2024, dynamics have changed. With Assad’s departure, ISIS lost its long-standing and vitally important safe haven in Syria’s central desert and its most significant driver for recruitment. The results — so far — have been dramatic.

The work of the Syria Strategy Project and the considerable policy recommendations found in this report present a realistic and holistic vision for Syria’s recovery and reintegration into the international system.

Afghanistan’s neighborhood is in the midst of a consequential restructuring of its security architecture. Key regional actors Pakistan, Afghanistan, Iran, and China have been continuing to adjust their defense plans and security partnerships to meet the growing threats posed by domestic and cross-border terrorism. At the same time, these four countries have also been looking for new ways to fill the vacuum in southern Asia left by the United States military’s departure from Afghanistan.

Normalizing regular contacts and building relationships with the Taliban leadership can offer a more effective way to hold the Islamic Emirate to account for its actions. It also gives greater promise of realizing American hopes for an Afghanistan inhospitable to global terrorists and more respectful of the human rights of its citizens.

This perilous moment for Syria’s future comes at a moment when American foreign policy in the region could change on a dime. President-elect Donald Trump has already stated the United States should have “nothing to do” with Syria’s future. But to do nothing would give the Islamic State a chance to surge once again.

Read MEI’s weekly briefing featuring expert analysis of key regional developments for the week ahead.

Russia’s full-scale war against Ukraine has provided several strategic opportunities for Iran to increase its foothold in the Greater Black Sea Region. A closer analysis of Iran’s deepening footprint there is necessary to inform how the next administration in Washington and the new European Commission can strengthen and better coordinate their policy responses.