Gulf and Arabian Peninsula

It is no surprise that both Iran and the United States have approached their first diplomatic engagement in four years with wariness. There are plenty of reasons to be skeptical about the probability of the negotiations culminating in a deal. But it would be a mistake to assume that the conditions in 2025 are the same as existed in 2015. Time is not on the Iranians’ side now and changes afoot in the Middle East and the broader global community give Iran an incentive to move toward an agreement, assuming that Washington is sincere and realistic in its negotiations with Tehran.

This article is published as part of the Perry World House workshop “U.S.-Iran Relations Under Trump 2.0: Lessons Learned and Likely Scenarios.”

The biggest development this past week in the Middle East policy of Trump’s second administration was the initiation of talks between the United States and Iran. This small sign of hope for diplomatic progress comes at a time when the administration continues to implement an assertive and unpredictable economic unilateralism that has roiled global markets and reduced trust and confidence between the United States and most close international partners. Brian Katulis unpacks three things to watch closely as Trump’s Iran policy evolves and his broader national security approach unfolds.

Sheikh Tahnoon bin Zayed, the United Arab Emirates’ national security adviser and a central figure in its tech and security landscape, visited Washington for high-level engagement with President Donald Trump’s team late last month, signaling a transformative shift in UAE-US relations.

The MENA Energy Recap is a quarterly review of key energy developments that took place in the Middle East and North Africa region from January to March 2025 and what they signal for the months ahead. The Recap views these developments through the lenses of policy and strategy, energy security, and markets.

US President Donald Trump surprised Israeli Prime Minister Benjamin Netanyahu by publicly announcing “direct” talks between the United States and Iran set to take place later this week. The American president also unleashed global economic uncertainty by announcing simultaneous, unexpectedly high tariffs on dozens of countries around the world — including a 17% duty on Israel — and kicking off an escalating global trade war.

President Donald Trump confirmed this week that he plans to travel to Saudi Arabia and other Middle East countries later this spring. This visit will bring the region into sharper focus at a time when Trump’s priorities have focused closer to home and on his unique brand of economic warfare.

President Donald Trump is focused on realizing two transformative breakthroughs that his predecessors failed to accomplish: an end to the Arab-Israeli conflict, centered on a tripartite US-Saudi-Israeli deal, and an agreement between the US and Iran. Both would be historic achievements. So far, however, progress in each case has proven difficult and plodding.

President Masoud Pezeshkian might be the loneliest man in Iran. Just eight months into his term in office, he is already losing the support of those who once championed him. While the Iranian presidency is a thankless job, Pezeshkian is not helping his own case.

The leaked Signal chat among top US administration officials discussing military strikes against the Houthis laid bare the central problems with Trump 2.0’s nascent national security approach: a strong inclination to prioritize tactics and propaganda in statecraft without a clear and practical strategic framework to deal with the biggest challenges in the world and in the Middle East.

Iran is accumulating enough near-weapons-grade enriched uranium to build a nuclear weapon within weeks or months, not years. President Donald Trump, having withdrawn the United States in 2018 from the nuclear deal that would have postponed that possibility, is now appealing for negotiations with Tehran. But in the Middle East, the nuclear question does not concern only Iran.

President Donald Trump’s administration dialed up its use of military power in the Middle East this past week just as it took more steps to dismantle American institutions central to advancing peace and stability through diplomacy.

In response to the request for information (RFI) from the National Science Foundation (NSF) and the Office of Science and Technology Policy (OSTP) regarding the “Development of an Artificial Intelligence Action Plan” in support of the objectives set forth in Executive Order (EO) 14179, the Middle East Institute (MEI) offers five recommendations to solidify the United States’ position as the global leader in AI innovation while addressing critical ethical, regulatory, and infrastructural imperatives.

After decades of managing tensions through careful balancing, Turkey and Iran now find themselves increasingly at odds following recent shifts in the regional balance of power. With Ankara emboldened and Tehran on its back foot after the fall of the regime of Bashar al-Assad, the struggle for influence between the two neighbors and long-time rivals is escalating in both Syria and Iraq and could spread well beyond their borders.