Research & Commentary Results

Following seven years of diplomatic deadlock, Washington and Tehran have resumed nuclear negotiations — and for the first time in years, there are signs of real momentum.

Alex Vatanka, MEI Senior Fellow and author of The Battle of the Ayatollahs in Iran, joins hosts Alistair Taylor and Matthew Czekaj to analyze the current round of talks, the technical issues under discussion, and the political stakes on both sides. He explores Iran’s economic and domestic pressures, US red lines, and the role of key players like Israel, China, and Oman in shaping the negotiations.

President Donald Trump wants a deal with Iran. Russia has offered to mediate. But an agreement negotiated by Moscow would turn the Middle East upside down as well as negate years of Western efforts to impede and deter further aggression by the Kremlin.

On April 12, the United States and Iran wrapped up their first round of renewed diplomatic talks in Muscat, with round two set for April 19, in Rome. In the interim, Iranian Foreign Minister Abbas Araghchi is in Moscow to coordinate with the Russians. But the real breakthrough will not come from nuclear talks alone — it will require confronting the region’s most explosive fault line: the Iranian-Israeli standoff. Russia claims it can help.

This article is published as part of the Perry World House workshop “U.S.-Iran Relations Under Trump 2.0: Lessons Learned and Likely Scenarios.”

For much of the past two decades, ISIS has enjoyed favorable conditions in Syria, but since the fall of Bashar al-Assad’s regime in December 2024, dynamics have changed. With Assad’s departure, ISIS lost its long-standing and vitally important safe haven in Syria’s central desert and its most significant driver for recruitment. The results — so far — have been dramatic.

The work of the Syria Strategy Project and the considerable policy recommendations found in this report present a realistic and holistic vision for Syria’s recovery and reintegration into the international system.

Afghanistan’s neighborhood is in the midst of a consequential restructuring of its security architecture. Key regional actors Pakistan, Afghanistan, Iran, and China have been continuing to adjust their defense plans and security partnerships to meet the growing threats posed by domestic and cross-border terrorism. At the same time, these four countries have also been looking for new ways to fill the vacuum in southern Asia left by the United States military’s departure from Afghanistan.

Normalizing regular contacts and building relationships with the Taliban leadership can offer a more effective way to hold the Islamic Emirate to account for its actions. It also gives greater promise of realizing American hopes for an Afghanistan inhospitable to global terrorists and more respectful of the human rights of its citizens.

This perilous moment for Syria’s future comes at a moment when American foreign policy in the region could change on a dime. President-elect Donald Trump has already stated the United States should have “nothing to do” with Syria’s future. But to do nothing would give the Islamic State a chance to surge once again.

Read MEI’s weekly briefing featuring expert analysis of key regional developments for the week ahead.

Russia’s full-scale war against Ukraine has provided several strategic opportunities for Iran to increase its foothold in the Greater Black Sea Region. A closer analysis of Iran’s deepening footprint there is necessary to inform how the next administration in Washington and the new European Commission can strengthen and better coordinate their policy responses.

Last month, the US electorate voted President-Elect Donald Trump back into the White House. His victory was seen by some experts as part of a global trend and a move towards anti-incumbency attitudes and populism. How will Trump’s rhetoric impact the United States domestically and internationally? Will he govern as a strongman during his second term? What can we expect to be different from his first term?

In only six days, a broad coalition of advancing opposition forces coordinated by Hayat Tahrir al-Sham has captured all of Idlib province, almost all of Aleppo province, and a sizeable stretch of northern Hama — a humiliating defeat for Bashar al-Assad and illustrative of the fragility of regime rule in Syria.

The Persian Gulf-Black Sea International Transport and Transit Corridor, which Tehran proposed eight years ago, remains relevant today in the context of strategic competition, as it offers Iran and participating countries an alternative trade route that bypasses traditional Western-dominated shipping lanes, potentially reshaping regional economic dynamics and geopolitical influence.

To abandon the Syria mission now would bring no meaningful benefit to the US, but it would swiftly and significantly empower America’s adversaries, like ISIS, Iran, Russia, and Assad’s regime.