Research & Commentary Results

President Donald Trump reached the 100-day mark in his second term this week seeing a sharp drop in his domestic political standing. This comes less than two weeks before Trump embarks on a key Middle East trip to the Gulf. The administration may be looking to the presidential visit as a chance to achieve some progress, but the region remains fraught with uncertainty and US policy in the Middle East rarely provides domestic political dividends.

Iran appears to be reorienting its approach to diplomatic engagement with its neighbors and the West by prioritizing the economic benefits of cooperation. A possible withdrawal of support for the Houthis is the latest significant potential outcome of Iran’s shifting stance. The following are five factors to watch for as a Tehran under duress reformulates its policies.

President Donald Trump wants a deal with Iran. Russia has offered to mediate. But an agreement negotiated by Moscow would turn the Middle East upside down as well as negate years of Western efforts to impede and deter further aggression by the Kremlin.

It is no surprise that both Iran and the United States have approached their first diplomatic engagement in four years with wariness. There are plenty of reasons to be skeptical about the probability of the negotiations culminating in a deal. But it would be a mistake to assume that the conditions in 2025 are the same as existed in 2015. Time is not on the Iranians’ side now and changes afoot in the Middle East and the broader global community give Iran an incentive to move toward an agreement, assuming that Washington is sincere and realistic in its negotiations with Tehran.

The biggest development this past week in the Middle East policy of Trump’s second administration was the initiation of talks between the United States and Iran. This small sign of hope for diplomatic progress comes at a time when the administration continues to implement an assertive and unpredictable economic unilateralism that has roiled global markets and reduced trust and confidence between the United States and most close international partners. Brian Katulis unpacks three things to watch closely as Trump’s Iran policy evolves and his broader national security approach unfolds.

Sheikh Tahnoon bin Zayed, the United Arab Emirates’ national security adviser and a central figure in its tech and security landscape, visited Washington for high-level engagement with President Donald Trump’s team late last month, signaling a transformative shift in UAE-US relations.

The MENA Energy Recap is a quarterly review of key energy developments that took place in the Middle East and North Africa region from January to March 2025 and what they signal for the months ahead. The Recap views these developments through the lenses of policy and strategy, energy security, and markets.

For much of the past two decades, ISIS has enjoyed favorable conditions in Syria, but since the fall of Bashar al-Assad’s regime in December 2024, dynamics have changed. With Assad’s departure, ISIS lost its long-standing and vitally important safe haven in Syria’s central desert and its most significant driver for recruitment. The results — so far — have been dramatic.

President Donald Trump confirmed this week that he plans to travel to Saudi Arabia and other Middle East countries later this spring. This visit will bring the region into sharper focus at a time when Trump’s priorities have focused closer to home and on his unique brand of economic warfare.

President Donald Trump is focused on realizing two transformative breakthroughs that his predecessors failed to accomplish: an end to the Arab-Israeli conflict, centered on a tripartite US-Saudi-Israeli deal, and an agreement between the US and Iran. Both would be historic achievements. So far, however, progress in each case has proven difficult and plodding.

The leaked Signal chat among top US administration officials discussing military strikes against the Houthis laid bare the central problems with Trump 2.0’s nascent national security approach: a strong inclination to prioritize tactics and propaganda in statecraft without a clear and practical strategic framework to deal with the biggest challenges in the world and in the Middle East.

Iran is accumulating enough near-weapons-grade enriched uranium to build a nuclear weapon within weeks or months, not years. President Donald Trump, having withdrawn the United States in 2018 from the nuclear deal that would have postponed that possibility, is now appealing for negotiations with Tehran. But in the Middle East, the nuclear question does not concern only Iran.

In response to the request for information (RFI) from the National Science Foundation (NSF) and the Office of Science and Technology Policy (OSTP) regarding the “Development of an Artificial Intelligence Action Plan” in support of the objectives set forth in Executive Order (EO) 14179, the Middle East Institute (MEI) offers five recommendations to solidify the United States’ position as the global leader in AI innovation while addressing critical ethical, regulatory, and infrastructural imperatives.

The work of the Syria Strategy Project and the considerable policy recommendations found in this report present a realistic and holistic vision for Syria’s recovery and reintegration into the international system.

Syria’s national dialogue, held in Damascus at the end of February, was intended to chart the country’s future, one that would have been unthinkable just three months earlier. However, the process and outcomes of the dialogue were flawed, left critical questions unanswered, and raised new concerns.