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On April 12, the United States and Iran wrapped up their first round of renewed diplomatic talks in Muscat, with round two set for April 19, in Rome. In the interim, Iranian Foreign Minister Abbas Araghchi is in Moscow to coordinate with the Russians. But the real breakthrough will not come from nuclear talks alone — it will require confronting the region’s most explosive fault line: the Iranian-Israeli standoff. Russia claims it can help.

It is no surprise that both Iran and the United States have approached their first diplomatic engagement in four years with wariness. There are plenty of reasons to be skeptical about the probability of the negotiations culminating in a deal. But it would be a mistake to assume that the conditions in 2025 are the same as existed in 2015. Time is not on the Iranians’ side now and changes afoot in the Middle East and the broader global community give Iran an incentive to move toward an agreement, assuming that Washington is sincere and realistic in its negotiations with Tehran.

This article is published as part of the Perry World House workshop “U.S.-Iran Relations Under Trump 2.0: Lessons Learned and Likely Scenarios.”

The biggest development this past week in the Middle East policy of Trump’s second administration was the initiation of talks between the United States and Iran. This small sign of hope for diplomatic progress comes at a time when the administration continues to implement an assertive and unpredictable economic unilateralism that has roiled global markets and reduced trust and confidence between the United States and most close international partners. Brian Katulis unpacks three things to watch closely as Trump’s Iran policy evolves and his broader national security approach unfolds.

US President Donald Trump surprised Israeli Prime Minister Benjamin Netanyahu by publicly announcing “direct” talks between the United States and Iran set to take place later this week. The American president also unleashed global economic uncertainty by announcing simultaneous, unexpectedly high tariffs on dozens of countries around the world — including a 17% duty on Israel — and kicking off an escalating global trade war.

Climate variability is becoming a key factor in shaping economic stability, agricultural productivity, and water security worldwide. Periods of prolonged drought and sudden shifts in precipitation can have far-reaching consequences, particularly for countries that rely heavily on natural water sources for farming and economic growth. As weather patterns become increasingly unpredictable, there is a need to navigate both the immediate impacts of climate change and the long-term strategies needed for climate resilience. Finding the right balance between short-term relief and sustainable adaptation is a fundamental challenge for economies dependent on agriculture and water availability. Nowhere is this more evident than in Morocco.

أكد الرئيس دونالد ترامب هذا الأسبوع أنه يخطط للسفر إلى المملكة العربية السعودية ودول أخرى في الشرق الأوسط في أواخر الربيع الحالي. وستسلط هذه الزيارة الضوء على المنطقة في وقت تركز فيه أولويات ترامب على الشؤون الداخلية وعلى أسلوبه الفريد في الحرب الاقتصادية.

يركز الرئيس دونالد ترامب على تحقيق إنجازين تحويليين فشل أسلافه في تحقيقهما: إنهاء الصراع العربي الإسرائيلي، الذي يتمحور حول اتفاق ثلاثي بين الولايات المتحدة والسعودية وإسرائيل، واتفاق بين الولايات المتحدة وإيران. وكلاهما سيكون إنجازًا تاريخيًا. لكن حتى الآن، ثبت أن التقدم في كلتا الحالتين صعب ومتعثر.

President Masoud Pezeshkian might be the loneliest man in Iran. Just eight months into his term in office, he is already losing the support of those who once championed him. While the Iranian presidency is a thankless job, Pezeshkian is not helping his own case.

تقوم إيران بتخزين ما يكفي من اليورانيوم المخصب القريب من الدرجة العسكرية لصنع سلاح نووي في غضون أسابيع أو أشهر، وليس سنوات. والرئيس دونالد ترامب، الذي انسحب في عام 2018 من الاتفاق النووي الذي كان من شأنه تأجيل هذه الإمكانية، يناشد الآن إجراء مفاوضات مع طهران. لكن في الشرق الأوسط، لا تقتصر المسألة النووية على إيران وحدها.

تولي دول شمال أفريقيا ودول العالم بشكل متزايد الأولوية لتعريف صارم للسيادة وتميل نحو الدبلوماسية التبادلية. إن فهم الدوافع الكامنة وراء نهج "السيادة أولاً" الذي تتبعه شمال أفريقيا يمكن أن يساعد الولايات المتحدة وأوروبا على بناء علاقات متبادلة المنفعة ودائمة مع المنطقة في ظل هذا الواقع الجديد.

عززت إدارة الرئيس دونالد ترامب استخدامها للقوة العسكرية في الشرق الأوسط الأسبوع الماضي، في الوقت الذي اتخذت فيه المزيد من الخطوات لتفكيك المؤسسات الأمريكية الأساسية لتعزيز السلام والاستقرار من خلال الدبلوماسية.

After decades of managing tensions through careful balancing, Turkey and Iran now find themselves increasingly at odds following recent shifts in the regional balance of power. With Ankara emboldened and Tehran on its back foot after the fall of the regime of Bashar al-Assad, the struggle for influence between the two neighbors and long-time rivals is escalating in both Syria and Iraq and could spread well beyond their borders.

While most media attention was focused on its global economic policy moves, the Trump administration continued to keep the Middle East high on its agenda this past week, with the president sending a letter to Iran’s supreme leader and his team directly engaging with the Palestinian group Hamas. This continued engagement on the region’s top two strategic questions, Iran and Arab-Israel affairs, contrasted with America’s hands-off approach to Syria, which saw some troubling violence.

President Donald Trump’s joint address to Congress on March 4 doubled down on his disruptive and contentious domestic policy agenda. Foreign policy, including Trump’s approach to the Middle East, was mostly an afterthought. Though he said little about Middle East policy in his speech, Trump’s team is taking an irregular approach on the twin issues of Israel-Arab ties and Iran that may not produce the stability and prosperity it seeks.