Sara Sadek

President Donald Trump wants a deal with Iran. Russia has offered to mediate. But an agreement negotiated by Moscow would turn the Middle East upside down as well as negate years of Western efforts to impede and deter further aggression by the Kremlin.

On April 12, the United States and Iran wrapped up their first round of renewed diplomatic talks in Muscat, with round two set for April 19, in Rome. In the interim, Iranian Foreign Minister Abbas Araghchi is in Moscow to coordinate with the Russians. But the real breakthrough will not come from nuclear talks alone — it will require confronting the region’s most explosive fault line: the Iranian-Israeli standoff. Russia claims it can help.

It is no surprise that both Iran and the United States have approached their first diplomatic engagement in four years with wariness. There are plenty of reasons to be skeptical about the probability of the negotiations culminating in a deal. But it would be a mistake to assume that the conditions in 2025 are the same as existed in 2015. Time is not on the Iranians’ side now and changes afoot in the Middle East and the broader global community give Iran an incentive to move toward an agreement, assuming that Washington is sincere and realistic in its negotiations with Tehran.

For months, Turkey’s government has been trying to accomplish three major tasks simultaneously or nearly so to solidify its hold on power at home and enhance its influence in the broader region. Its three-pronged approach to fulfilling that goal consists of seeking to 1) crush democracy and destroy the political opposition in Turkey by bringing serious criminal charges against Ekrem İmamoğlu, the popular mayor of Istanbul; 2) bring Turkey’s pro-Kurdish party into a coalition to win the next national election with current President Recep Tayyip Erdoğan continuing his 22-year rule; and 3) leverage its new and powerful influence in Syria to neutralize Kurdish power in the northeast and in the Syrian national government.

As Sudan’s civil war enters its third year, the humanitarian catastrophe continues to spiral, with more than 12.7 million people displaced and little hope of resolution in sight.

Jehanne Henry, MEI Associate Fellow and former Africa Director at Human Rights Watch, joins hosts Alistair Taylor and Matthew Czekaj to assess the latest developments on the ground. She outlines the scale of devastation, the regional spillover effects, and the war economy fueling the fighting.

This article is published as part of the Perry World House workshop “U.S.-Iran Relations Under Trump 2.0: Lessons Learned and Likely Scenarios.”

The biggest development this past week in the Middle East policy of Trump’s second administration was the initiation of talks between the United States and Iran. This small sign of hope for diplomatic progress comes at a time when the administration continues to implement an assertive and unpredictable economic unilateralism that has roiled global markets and reduced trust and confidence between the United States and most close international partners. Brian Katulis unpacks three things to watch closely as Trump’s Iran policy evolves and his broader national security approach unfolds.

Sheikh Tahnoon bin Zayed, the United Arab Emirates’ national security adviser and a central figure in its tech and security landscape, visited Washington for high-level engagement with President Donald Trump’s team late last month, signaling a transformative shift in UAE-US relations.

The MENA Energy Recap is a quarterly review of key energy developments that took place in the Middle East and North Africa region from January to March 2025 and what they signal for the months ahead. The Recap views these developments through the lenses of policy and strategy, energy security, and markets.

For much of the past two decades, ISIS has enjoyed favorable conditions in Syria, but since the fall of Bashar al-Assad’s regime in December 2024, dynamics have changed. With Assad’s departure, ISIS lost its long-standing and vitally important safe haven in Syria’s central desert and its most significant driver for recruitment. The results — so far — have been dramatic.

Two years on, the war between the Sudanese Armed Forces and the paramilitary Rapid Support Forces has created the world’s largest humanitarian crisis and wrought terrible destruction.

(This episode was recorded on Monday, April 7).

In this episode of Middle East Focus, hosts Alistair Taylor and Matthew Czekaj are joined by Eran Etzion, former deputy head of the Israeli National Security Council, for a revealing look inside Israel’s most pressing challenges.

US President Donald Trump surprised Israeli Prime Minister Benjamin Netanyahu by publicly announcing “direct” talks between the United States and Iran set to take place later this week. The American president also unleashed global economic uncertainty by announcing simultaneous, unexpectedly high tariffs on dozens of countries around the world — including a 17% duty on Israel — and kicking off an escalating global trade war.