Whenever Iran is shaken by nationwide protests, as it was just last month, analysts and activists are consumed by the same two questions: will the country’s regime finally fall, and what will come next if it does? Answers abound.
Donald Trump’s first year of his second presidential term has been a roller coaster of twists and turns both at home and abroad—particularly in the Middle East. His regional focus was driven by two main factors: first, Trump’s own ego and sense of possible place in history; and second, the volatile, dynamic events driven by actors in the region.
In the first year of his second term in office, US President Donald Trump focused considerable time and energy on the Middle East, but the results so far have been uneven. This report assesses the US government’s actions in the region over the past 12 months, from January 2025 through January 2026.
Hosts Alistair Taylor and Matthew Czekaj are joined by MEI Distinguished Military Fellow Mick Mulroy to discuss the Trump administration’s new National Defense Strategy (NDS) and its implications for the Middle East. While serving as the Deputy Assistant Secretary of Defense (DASD) for the Middle East from 2017 to 2019, Mulroy helped prepare the 2018 NDS, giving him an insider perspective on US defense planning. Together, Taylor, Czekaj, and Mulroy unpack what the new strategy means for US priorities globally and for the Middle East in particular, including how it could be reflected in a potentially looming military strike on Iran.
The decision by Washington and Tehran to shift their long-anticipated meeting, set for February 6, from Istanbul to Muscat is not merely a logistical detail. It is the latest reminder that when US-Iran diplomacy is on the verge of breaking down completely, Oman is the regional player the Iranian regime trusts the most to step in and mediate.
From a US military build-up in the region to Trump’s growing unpopularity at home, several factors could influence his decision on whether or not to attack.
Pakistan’s relationship with the Afghan Taliban has shifted from open sponsorship in the 1990s to a silent partnership following 2001 to alienation and belligerence since 2021. Their current conflict, which comes at great cost to both countries and seems to have no easy military or political resolution, also poses a threat to the stability and prosperity of neighboring states. Although American strategic interests in the region greatly diminished following the United States’ military withdrawal from Afghanistan in August 2021, the region’s altered political dynamics have prompted a growing American engagement with Pakistan and tentatively with Afghanistan. At the same time, the US has become a factor in how both Islamabad and Kabul have come to form their national security strategies.
Brian sits down with Behnam Taleblu, Senior Fellow at the Foundation for Defense of Democracies, to unpack the ongoing protests in Iran and what this moment reveals about the long struggle between the state and the street. They discuss the regime’s brutal crackdown, the prospect of US intervention, and what both could mean for the future of the Islamic Republic. The episode centers on agency, imagination, and the possibilities facing Iranians at a critical juncture in the country’s history.
The collapse of the Iranian regime in its present form now seems more plausible than its survival as a functioning state. Yet the emergence of a democratic Iran remains far from certain. Between these two outcomes lies a volatile and dangerous middle ground. But much will depend on four factors.
President Donald Trump has sharply warned the Iranian regime to halt its brutal crackdown on protesters. Amid speculation that the US is preparing for military action in Iran, Washington should take the lessons and fundamentally different context of its successful June 2025 operation against the Islamic Republic into account as it plans for how to respond.
People are not protesting because they suddenly discovered activism. They are protesting because the habits of coping and waiting for conditions to improve have finally stopped working.
Last week, Iran’s Supreme Leader Ali Khamenei effectively greenlit mass killing to save his regime. His message was blunt: blood would be spilled to preserve the system. His security forces followed through, unleashing a level of violence against protesters that even by the Islamic Republic’s grim standards marks a dangerous escalation.
